Is Protein The Most Satiating Macronutrient?

This idea that protein is far and away the most satiating macronutrient primarily comes from the bodybuilding world and mechanistic research on hunger hormones like GLP-1, PYY, and Ghrelin, combined with subjective appetite questionnaires [1-5].

But, there has been a significant amount of pushback recently on the practical significance of this ideology.

We can begin to see the nuance of this subject from an interesting vantage point–an undernourished elderly population who actually doesn’t want the potential appetite suppression of protein, as these specific individuals need to consume more calories and more protein.